PPP1CA

Across TCGA patient cohorts, PPP1CA protein abundance is significantly associated with the RNA expression of many other genes, with 11,317 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPP1CA-associated genes across cancer lineages are CD80, CGAS, and PTAFR. Each is linked with PPP1CA in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP1CA-to-partner and partner-to-PPP1CA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1CA versus CD80 in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CA→partner) and Y-score (partner→PPP1CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD80 →	+0.780	+0.201	.001	.006	3	5
LSCC	CGAS →	+0.703	+0.181	<.001	<.001	3	5
UCEC	PTAFR →	+1.023	+0.208	<.001	.003	3	5
LUAD	PSMB10 →	+0.442	+0.123	<.001	.001	3	5
HNSC	IFT27 →	-0.710	-0.313	<.001	<.001	3	4
LSCC	CSF2RB →	+0.793	+0.265	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,317 associations by consensus.

PPP1CA vs CD80 — UCEC

Explore this scatter interactively →