PPP1CA

Across TCGA patient cohorts, PPP1CA mutation is significantly associated with the RNA expression of many other genes, with 165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1CA-associated genes across cancer lineages are RN7SL783P, RNA5SP501, and MIR5091. Each is linked with PPP1CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CA-to-partner and partner-to-PPP1CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL783P grouped by PPP1CA-low versus PPP1CA-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CA→partner) and Y-score (partner→PPP1CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL783P →	+0.219	+4.993	<.001	.002	3	2
SKCM	RNA5SP501 →	+2.311	+4.970	<.001	.005	3	2
UCEC	MIR5091 →	+0.533	+2.186	.002	.006	3	2
BRCA	RN7SL722P →	+0.164	+8.471	<.001	.005	3	1
UCEC	NUTF2P8 →	+0.109	+2.813	<.001	.005	3	1
UCEC	USP37P1 →	+0.070	+4.010	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 165 associations by consensus.

RN7SL783P by PPP1CA expression — LUSC

Explore this box plot interactively →