PPP1CA

Across TCGA patient cohorts, PPP1CA mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1CA-associated genes across cancer lineages are eEF2, PDCD4, and GSK-3_pS9. Each is linked with PPP1CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CA-to-partner and partner-to-PPP1CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PPP1CA-low versus PPP1CA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CA→partner) and Y-score (partner→PPP1CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.371	+2.321	.039	.035	3	1
UCEC	PDCD4 →	-0.805	-3.459	<.001	.005	3	1
UCEC	GSK-3_pS9 →	-0.584	-3.000	.003	.036	2	1
UCEC	Caspase-8 →	-0.252	-2.321	.046	.035	2	1
UCEC	TIGAR →	+0.232	+3.486	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

eEF2 by PPP1CA expression — UCEC

Explore this box plot interactively →