PPP1CA

Across TCGA cell cohorts, PPP1CA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,983 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1CA-associated GO terms across cancer lineages are CAAX-box protein processing, Positive regulation of attachment of mitotic spindle microtubules to kinetochore, and Regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with PPP1CA in more than 13 cancer types. Because this analysis shows association rather than direction, both PPP1CA-to-partner and partner-to-PPP1CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAX-box protein processing grouped by PPP1CA-low versus PPP1CA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CA→partner) and Y-score (partner→PPP1CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAAX-box protein processing →	+0.222	+1.138	<.001	<.001	3	14
LARGE_INTESTINE	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.128	+0.635	<.001	<.001	3	14
SOFT_TISSUE	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.166	+1.004	<.001	<.001	3	13
SOFT_TISSUE	Spindle elongation →	+0.235	+0.911	<.001	<.001	3	12
SOFT_TISSUE	Regulation of metaphase plate congression →	+0.105	+0.713	<.001	<.001	3	12
OVARY	Regulation of cell cycle checkpoint →	+0.109	+0.767	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,983 associations by consensus.

CAAX-box protein processing by PPP1CA expression — BONE

Explore this box plot interactively →