PPP1CA

Across TCGA cell cohorts, PPP1CA mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1CA-associated genes across cancer lineages are CLDN17, SCGB3A2, and GKN1. Each is linked with PPP1CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CA-to-partner and partner-to-PPP1CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by PPP1CA-low versus PPP1CA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CA→partner) and Y-score (partner→PPP1CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLDN17 →	+0.066	+4.930	<.001	.001	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.384	+4.095	<.001	.009	3	1
LARGE_INTESTINE	GKN1 →	+0.077	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.287	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1
BREAST	CCDC105 →	+0.006	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLDN17 by PPP1CA expression — LARGE_INTESTINE

Explore this box plot interactively →