PPOX

Across TCGA pan-cancer cohorts, PPOX mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPOX data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPOX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPOX expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where PPOX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.774	0.495	.025	13	view →
PDAC	OS	Tertile	III,IV	0.683	0.114	.011	13	view →
HNSC	DFS	Quartile	II,III,IV	0.706	0.884	.010	12	view →
CCRCC	DFS	Tertile	IV	0.260	0.887	.024	10	view →
LSCC	DFS	Quartile	II,III,IV	0.845	1.000	.015	9	view →
GBM	OS	Median	All	0.282	0.505	.011	6	view →
UCEC	OS	Median	All	0.862	0.965	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPOX–LUAD (OS)

Open the LUAD breakdown →