PPOX

Across TCGA patient cohorts, PPOX mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPOX-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with PPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PPOX-to-partner and partner-to-PPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPOX-low versus PPOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPOX→partner) and Y-score (partner→PPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.145	-2.308	.003	.036	3	1
UCEC	EGFR_pY1068 →	-0.331	-2.321	.008	.035	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.321	.031	.035	3	1
UCEC	Heregulin →	-0.206	-3.459	<.001	.005	3	1
UCEC	MEK1 →	+0.417	+2.321	.023	.035	3	1
UCEC	MSH6 →	-0.620	-2.311	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

14-3-3_beta by PPOX expression — UCEC

Explore this box plot interactively →