PPOX

Across TCGA cell cohorts, PPOX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,957 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPOX-associated GO terms across cancer lineages are Protoporphyrinogen IX biosynthetic process, Protoporphyrinogen IX metabolic process, and Heme B biosynthetic process. Each is linked with PPOX in more than 17 cancer types. Because this analysis shows association rather than direction, both PPOX-to-partner and partner-to-PPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protoporphyrinogen IX biosynthetic process grouped by PPOX-low versus PPOX-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPOX→partner) and Y-score (partner→PPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protoporphyrinogen IX biosynthetic process →	+0.133	+0.948	<.001	<.001	3	18
URINARY_TRACT	Protoporphyrinogen IX metabolic process →	+0.171	+1.483	<.001	<.001	3	15
URINARY_TRACT	Heme B biosynthetic process →	+0.171	+1.483	<.001	<.001	3	15
BONE	Intraciliary retrograde transport →	+0.075	+0.736	<.001	<.001	3	13
BONE	Intraciliary transport →	+0.083	+1.008	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Heme A biosynthetic process →	+0.121	+0.892	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,957 associations by consensus.

Protoporphyrinogen IX biosynthetic process by PPOX expression — OESOPHAGUS

Explore this box plot interactively →