Across TCGA patient cohorts, PPME1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,392 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPME1-associated genes across cancer lineages are RAB6A, STARD10, and TNFSF8. Each is linked with PPME1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PPME1-to-partner and partner-to-PPME1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPME1→partner) and Y-score (partner→PPME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAB6A →	+0.657	+0.340	<.001	<.001	3	7
HNSC	STARD10 →	+0.998	+0.339	.001	.008	3	6
GBM	TNFSF8 →	-0.933	-0.272	<.001	<.001	3	6
HNSC	PSTPIP1 →	-0.830	-0.291	.001	.001	3	6
OV	C1orf162 →	-0.823	-0.349	<.001	.001	3	6
CCRCC	CLEC1A →	-0.744	-0.239	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,392 associations by consensus.

Exploration

PPME1 survival (RNA) · tumor vs normal (RNA) · all PPME1 data types