Across TCGA patient cohorts, PPME1 mutation is significantly associated with the RNA expression of many other genes, with 2,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPME1-associated genes across cancer lineages are RNU6-97P, IL21, and F8A2. Each is linked with PPME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPME1-to-partner and partner-to-PPME1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPME1→partner) and Y-score (partner→PPME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-97P →	+0.756	+4.203	<.001	.003	3	2
UCEC	IL21 →	+0.192	+2.512	<.001	<.001	3	2
UCEC	F8A2 →	+0.019	+2.372	.001	.009	3	2
UCEC	LILRP1 →	+0.076	+1.699	.003	.003	3	2
UCEC	RNU6-151P →	+0.353	+2.255	.001	<.001	3	2
UCEC	TRAJ54 →	+0.330	+2.014	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,197 associations by consensus.

Exploration

PPME1 survival (RNA) · tumor vs normal (RNA) · all PPME1 data types