Across TCGA patient cohorts, PPME1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPME1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with PPME1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPME1-to-partner and partner-to-PPME1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPME1→partner) and Y-score (partner→PPME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.088	-2.973	.025	.035	3	1
UCEC	eEF2 →	+0.413	+2.000	.003	.010	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.000	.004	.010	3	1
UCEC	eIF4E →	+0.236	+3.598	.004	.001	3	1
UCEC	A-Raf_pS299 →	-0.138	-2.999	.003	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.690	.045	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

PPME1 survival (RNA) · tumor vs normal (RNA) · all PPME1 data types