Across TCGA cell cohorts, PPME1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,833 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPME1-associated GO terms across cancer lineages are Centriole elongation, Negative regulation of post-translational protein modification, and Regulation of protein K48-linked ubiquitination. Each is linked with PPME1 in more than 15 cancer types. Because this analysis shows association rather than direction, both PPME1-to-partner and partner-to-PPME1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPME1→partner) and Y-score (partner→PPME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Centriole elongation →	+0.136	+0.886	<.001	<.001	3	16
BLOOD_Leukemia	Negative regulation of post-translational protein modification →	+0.051	+0.609	<.001	<.001	3	13
STOMACH	Regulation of protein K48-linked ubiquitination →	+0.159	+1.235	<.001	.001	3	12
PANCREAS	Negative regulation of protein modification by small protein conjugation or removal →	+0.063	+0.734	<.001	.005	3	11
PANCREAS	Spindle checkpoint signaling →	+0.131	+0.602	<.001	<.001	3	11
PANCREAS	Mitotic spindle elongation →	+0.253	+0.876	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,833 associations by consensus.

Exploration

PPME1 survival (RNA) · tumor vs normal (RNA) · all PPME1 data types