Across TCGA patient cohorts, PPM1N RNA expression is significantly associated with the protein abundance of many other proteins, with 10,528 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PPM1N-associated proteins across cancer lineages are ARPC5, SH3BGRL3, and CAPZA1. Each is linked with PPM1N in more than 4 cancer types. Because this analysis shows association rather than direction, both PPM1N-to-partner and partner-to-PPM1N results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1N→partner) and Y-score (partner→PPM1N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARPC5 →	+0.261	+0.328	<.001	<.001	3	4
PDAC	SH3BGRL3 →	+0.547	+0.745	<.001	<.001	3	4
PDAC	CAPZA1 →	+0.304	+0.406	<.001	.002	3	4
GBM	BTK →	+0.426	+0.314	<.001	<.001	3	4
GBM	FGD2 →	+0.464	+0.343	<.001	<.001	3	4
UCEC	FYB1 →	+0.483	+0.565	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,528 associations by consensus.

Exploration

PPM1N survival (RNA) · tumor vs normal (RNA) · all PPM1N data types