PPM1N

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PPM1N mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1N-associated genes across cancer lineages are INPP4B, PRAS40_pT246, and Tuberin_pT1462. Each is linked with PPM1N in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1N-to-partner and partner-to-PPM1N results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1N→partner) and Y-score (partner→PPM1N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECINPP4B →-0.398-3.321.008.01032
UCECPRAS40_pT246 →+0.189+1.887.018.03132
UCECTuberin_pT1462 →+0.355+3.321<.001.00932
UCECCaspase-7-cleavedD198 →+0.717+3.019.009.01932
UCECMEK1 →+0.459+2.584.007.01131
UCECAkt_pS473 →+0.910+3.000.006.03622
Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

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