PPM1M

Across TCGA pan-cancer cohorts, PPM1M Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1M data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPM1M Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPM1M expression acts as an unfavorable survival marker.

HNSC, BLCA, and UCEC are the cancer types where PPM1M Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.710	.001	24	view →
BLCA	DFS	Median	All	0.132	0.626	.006	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	OS	Median	All	0.424	0.785	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1M–HNSC (OS)

Open the HNSC breakdown →