PPM1M

Across TCGA pan-cancer cohorts, PPM1M mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPM1M data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPM1M mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1M expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where PPM1M mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.974	0.424	.016	8	view →
GBM	DFS	Quartile	All	0.291	0.615	.005	8	view →
PDAC	OS	Tertile	III,IV	0.344	1.000	.036	6	view →
LSCC	DFS	Tertile	II,III,IV	0.483	0.828	.032	2	view →
LUAD	DFS	Tertile	II,III,IV	0.726	1.000	.018	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPM1M–CCRCC (DFS)

Open the CCRCC breakdown →