PPM1M

Across TCGA pan-cancer cohorts, PPM1M mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPM1M’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PPM1M mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPM1M is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where PPM1M tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1M mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.663	<.001	8	view →
LUAD	Male	II,III,IV	−0.307	<.001	7	view →
CCRCC	Female	All	+0.668	<.001	6	view →
COAD	All	All	−0.583	.048	4	view →
PDAC	Male	III,IV	−0.463	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPM1M–LSCC

Open the LSCC breakdown →