PPM1M

Across TCGA patient cohorts, PPM1M mutation is significantly associated with the RNA expression of many other genes, with 1,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1M-associated genes across cancer lineages are MIR6894, RNY3P7, and RPS28P1. Each is linked with PPM1M in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1M-to-partner and partner-to-PPM1M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by PPM1M-low versus PPM1M-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1M→partner) and Y-score (partner→PPM1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6894 →	+0.628	+5.506	<.001	.005	3	2
COAD	RNY3P7 →	+0.217	+4.595	<.001	.004	3	2
UCEC	RPS28P1 →	+0.103	+2.912	<.001	.009	3	2
UCEC	MIR7702 →	+0.229	+4.253	<.001	.004	3	2
UCEC	MIR4311 →	+0.296	+2.214	.006	.009	3	2
LIHC	RNU6-1082P →	+0.628	+5.108	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,262 associations by consensus.

MIR6894 by PPM1M expression — BRCA

Explore this box plot interactively →