PPM1M

Across TCGA patient cohorts, PPM1M mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1M-associated genes across cancer lineages are E-Cadherin, MSH2, and Notch1. Each is linked with PPM1M in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1M-to-partner and partner-to-PPM1M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E-Cadherin grouped by PPM1M-low versus PPM1M-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1M→partner) and Y-score (partner→PPM1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E-Cadherin →	-0.532	-2.990	.018	.036	3	2
UCEC	MSH2 →	-0.327	-2.584	.002	.011	3	1
UCEC	Notch1 →	+0.148	+3.009	.024	.019	3	1
UCEC	p62 Lck ligand →	+0.509	+2.321	<.001	.033	3	1
UCEC	Caspase-8 →	-0.265	-3.295	.023	.009	3	1
UCEC	C-Raf →	+0.137	+2.321	.040	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

E-Cadherin by PPM1M expression — UCEC

Explore this box plot interactively →