PPM1M

Across TCGA cell cohorts, PPM1M RNA expression is significantly associated with the go_rna of many other GO terms, with 3,455 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPM1M-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of telomere maintenance, and Positive regulation of synapse structural plasticity. Each is linked with PPM1M in more than 9 cancer types. Because this analysis shows association rather than direction, both PPM1M-to-partner and partner-to-PPM1M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by PPM1M-low versus PPM1M-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1M→partner) and Y-score (partner→PPM1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+0.837	<.001	<.001	3	10
URINARY_TRACT	Negative regulation of telomere maintenance →	+0.083	+1.382	<.001	.002	3	9
BLOOD_Lymphoma	Positive regulation of synapse structural plasticity →	+1.160	+1.117	<.001	.002	3	9
OVARY	Cell-cell adhesion mediated by cadherin →	-0.160	-0.601	<.001	.001	3	8
LUNG_NSCLC_LUSC	Heme A biosynthetic process →	+0.100	+1.033	.002	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.086	+0.823	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,455 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by PPM1M expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →