PPM1M

Across TCGA cell cohorts, PPM1M mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1M-associated genes across cancer lineages are VSX2, COX6A2, and ITGAD. Each is linked with PPM1M in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1M-to-partner and partner-to-PPM1M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSX2 grouped by PPM1M-low versus PPM1M-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1M→partner) and Y-score (partner→PPM1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSX2 →	+0.020	+3.994	<.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.011	+3.510	<.001	.003	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1F1 →	+0.430	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

VSX2 by PPM1M expression — LARGE_INTESTINE

Explore this box plot interactively →