PPM1K

Across TCGA pan-cancer cohorts, PPM1K mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPM1K data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPM1K mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPM1K expression acts as an unfavorable survival marker.

UCEC, LUAD, and PDAC are the cancer types where PPM1K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.253	1.000	.008	32	view →
LUAD	OS	Median	All	0.892	1.000	.004	14	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPM1K–UCEC (OS)

Open the UCEC breakdown →