PPM1K

Across TCGA patient cohorts, PPM1K mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1K-associated genes across cancer lineages are ASNS, EGFR_pY1068, and FASN. Each is linked with PPM1K in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1K-to-partner and partner-to-PPM1K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PPM1K-low versus PPM1K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1K→partner) and Y-score (partner→PPM1K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.419	+2.999	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.298	-2.459	.005	.019	3	1
UCEC	FASN →	+0.334	+2.222	.046	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.449	.019	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.191	-2.459	.007	.019	3	1
UCEC	MEK1 →	+0.411	+3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ASNS by PPM1K expression — UCEC

Explore this box plot interactively →