PPM1K

Across TCGA cell cohorts, PPM1K mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPM1K-associated genes across cancer lineages are OOSP2, OR9Q2, and TRIM43B. Each is linked with PPM1K in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1K-to-partner and partner-to-PPM1K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP2 grouped by PPM1K-low versus PPM1K-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1K→partner) and Y-score (partner→PPM1K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OOSP2 →	+0.016	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR9Q2 →	+0.062	+4.977	<.001	.007	3	1
BLOOD_Leukemia	TRIM43B →	+0.027	+3.234	<.001	.008	3	1
BLOOD_Leukemia	TPRX1 →	+0.008	+3.475	.001	.006	3	1
BLOOD_Leukemia	TAS2R39 →	+0.039	+3.339	.005	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.023	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OOSP2 by PPM1K expression — LARGE_INTESTINE

Explore this box plot interactively →