PPM1J

Across TCGA pan-cancer cohorts, PPM1J Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1J data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PPM1J Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPM1J expression acts as an unfavorable survival marker.

BLCA, SKCM, and LGG are the cancer types where PPM1J Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.177	0.711	<.001	51	view →
SKCM	DFS	Median	All	0.202	0.741	<.001	27	view →
LGG	OS	Median	All	0.187	0.909	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1J–BLCA (OS)

Open the BLCA breakdown →