PPM1J

Across TCGA pan-cancer cohorts, PPM1J mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PPM1J data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPM1J mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPM1J expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD and GBM are the cancer types where PPM1J mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.907	0.597	.003	17	view →
GBM	OS	Median	All	0.189	0.579	<.001	7	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PPM1J–LUAD (OS)

Open the LUAD breakdown →