PPM1J

Across TCGA pan-cancer cohorts, PPM1J mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PPM1J’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PPM1J mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPM1J is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

LUAD and LSCC are the cancer types where PPM1J tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1J mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+1.165	<.001	7	view →
LSCC	All	All	−0.629	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PPM1J–LUAD

Open the LUAD breakdown →