PPM1J

Across TCGA patient cohorts, PPM1J mutation is significantly associated with the RNA expression of many other genes, with 793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1J-associated genes across cancer lineages are RNA5SP486, RNU1-62P, and IGHV3OR16-8. Each is linked with PPM1J in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1J-to-partner and partner-to-PPM1J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP486 grouped by PPM1J-low versus PPM1J-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1J→partner) and Y-score (partner→PPM1J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP486 →	+0.588	+7.930	<.001	.008	3	3
CESC	RNU1-62P →	+0.238	+5.539	<.001	.004	3	2
UCEC	IGHV3OR16-8 →	+0.550	+2.824	.008	<.001	3	1
UCEC	CCL5 →	+1.088	+2.021	.002	.005	3	1
UCEC	ZNHIT3 →	+0.400	+2.021	.007	.005	3	1
UCEC	MIR7702 →	+0.181	+3.890	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

RNA5SP486 by PPM1J expression — LUAD

Explore this box plot interactively →