PPM1J

Across TCGA patient cohorts, PPM1J mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1J-associated genes across cancer lineages are EGFR_pY1068, GSK-3_pS9, and Ku80. Each is linked with PPM1J in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1J-to-partner and partner-to-PPM1J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPM1J-low versus PPM1J-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1J→partner) and Y-score (partner→PPM1J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.337	-2.906	.001	.001	3	1
UCEC	GSK-3_pS9 →	-0.674	-2.700	<.001	.006	3	1
UCEC	Ku80 →	+0.213	+1.713	.033	.027	3	1
UCEC	MSH2 →	-0.256	-3.143	.009	.018	3	1
UCEC	MSH6 →	-0.287	-3.169	.040	.018	3	1
UCEC	NF-kB-p65_pS536 →	-0.528	-3.169	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by PPM1J expression — UCEC

Explore this box plot interactively →