PPM1J

Across TCGA cell cohorts, PPM1J RNA expression is significantly associated with the go_rna of many other GO terms, with 3,160 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PPM1J-associated GO terms across cancer lineages are Regulation of myoblast fusion, Sperm mitochondrial sheath assembly, and Lipoprotein localization. Each is linked with PPM1J in more than 8 cancer types. Because this analysis shows association rather than direction, both PPM1J-to-partner and partner-to-PPM1J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PPM1J-low versus PPM1J-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1J→partner) and Y-score (partner→PPM1J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of myoblast fusion →	+0.082	+0.644	.003	.008	3	9
LARGE_INTESTINE	Sperm mitochondrial sheath assembly →	-0.207	-0.885	<.001	<.001	3	8
SKIN	Lipoprotein localization →	+0.109	+0.575	<.001	.004	2	9
BLOOD_Lymphoma	Positive regulation of lamellipodium organization →	+0.074	+0.827	.002	<.001	3	8
PANCREAS	Regulation of lamellipodium assembly →	+0.092	+0.597	.005	.001	3	7
LARGE_INTESTINE	Pyruvate import into mitochondria →	-0.134	-0.854	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,160 associations by consensus.

Regulation of myoblast fusion by PPM1J expression — KIDNEY

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