PPM1J

Across TCGA cell cohorts, PPM1J mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1J-associated genes across cancer lineages are KRTAP4-9, KRTAP4-2, and FAM25C. Each is linked with PPM1J in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1J-to-partner and partner-to-PPM1J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-9 grouped by PPM1J-low versus PPM1J-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1J→partner) and Y-score (partner→PPM1J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP4-9 →	+0.211	+4.044	<.001	.009	3	1
LUNG_SCLC	KRTAP4-2 →	+0.084	+4.643	<.001	.004	3	1
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1
OVARY	TMEM95 →	+0.022	+5.196	<.001	.005	3	1
OVARY	KIR3DL3 →	+0.054	+5.196	<.001	.005	3	1
LARGE_INTESTINE	TLX3 →	+0.438	+3.845	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KRTAP4-9 by PPM1J expression — LUNG_SCLC

Explore this box plot interactively →