PPM1G

Across TCGA pan-cancer cohorts, PPM1G mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPM1G data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPM1G mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPM1G expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where PPM1G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.331	0.802	<.001	30	view →
LSCC	OS	Median	II,III,IV	0.911	0.591	.002	24	view →
HNSC	DFS	Tertile	IV	0.502	0.788	.018	22	view →
LUAD	OS	Median	All	0.625	0.942	.013	12	view →
PDAC	DFS	Tertile	IV	0.749	0.217	.024	3	view →
GBM	DFS	Median	All	0.483	0.273	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPM1G–CCRCC (DFS)

Open the CCRCC breakdown →