PPM1G

Across TCGA patient cohorts, PPM1G mutation is significantly associated with the RNA expression of many other genes, with 4,708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1G-associated genes across cancer lineages are SNORD66, CWC25, and SYNRG. Each is linked with PPM1G in more than 2 cancer types. Because this analysis shows association rather than direction, both PPM1G-to-partner and partner-to-PPM1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD66 grouped by PPM1G-low versus PPM1G-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1G→partner) and Y-score (partner→PPM1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD66 →	+0.296	+3.046	<.001	.004	3	3
UCEC	CWC25 →	+0.355	+1.720	<.001	<.001	3	2
UCEC	SYNRG →	+0.399	+4.290	<.001	<.001	3	2
UCEC	SRCIN1 →	-0.708	-2.381	<.001	<.001	3	2
BLCA	FAAP24 →	+0.584	+3.329	.004	.005	3	2
BLCA	GPR119 →	+0.026	+2.928	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,708 associations by consensus.

SNORD66 by PPM1G expression — SKCM

Explore this box plot interactively →