PPM1G

Across TCGA patient cohorts, PPM1G mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1G-associated genes across cancer lineages are S6_pS240_S244, TFRC, and Caspase-7-cleavedD198. Each is linked with PPM1G in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1G-to-partner and partner-to-PPM1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by PPM1G-low versus PPM1G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1G→partner) and Y-score (partner→PPM1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.289	+1.584	.024	.034	3	2
UCEC	TFRC →	+0.428	+2.222	.010	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.728	+1.945	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.235	-1.836	.002	.001	3	1
UCEC	eIF4E →	+0.216	+3.598	.001	.001	3	1
UCEC	ERK2 →	+0.201	+3.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

S6_pS240_S244 by PPM1G expression — UCEC

Explore this box plot interactively →