PPM1D

Across TCGA pan-cancer cohorts, PPM1D Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPM1D data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPM1D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and LGG are the cancer types where PPM1D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.616	.003	36	view →
BLCA	OS	Median	III,IV	0.084	0.687	<.001	24	view →
LGG	OS	Median	All	0.270	0.799	.003	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPM1D–UCEC (DFS)

Open the UCEC breakdown →