PPM1D

Across TCGA pan-cancer cohorts, PPM1D mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPM1D data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPM1D mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1D expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, GBM, and LUAD are the cancer types where PPM1D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.799	0.551	.026	6	view →
GBM	OS	Median	All	0.208	0.740	.038	6	view →
LUAD	OS	Quartile	II,III,IV	0.866	0.393	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPM1D–LSCC (DFS)

Open the LSCC breakdown →