PPM1D

Across TCGA pan-cancer cohorts, PPM1D mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PPM1D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPM1D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPM1D is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC are the cancer types where PPM1D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−3.580	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

PPM1D–HNSC

Open the HNSC breakdown →