PPM1D

Across TCGA patient cohorts, PPM1D mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1D-associated genes across cancer lineages are p27_pT198, 14-3-3_beta, and eEF2. Each is linked with PPM1D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1D-to-partner and partner-to-PPM1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by PPM1D-low versus PPM1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1D→partner) and Y-score (partner→PPM1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.095	+1.807	.009	.004	3	2
UCEC	14-3-3_beta →	-0.086	-2.088	.011	.016	3	1
UCEC	eEF2 →	+0.313	+3.584	.010	.002	3	1
UCEC	EGFR_pY1068 →	-0.207	-2.000	.015	.009	3	1
UCEC	EGFR →	-0.130	-2.000	.016	.030	3	1
UCEC	eIF4E →	+0.172	+2.137	.016	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

p27_pT198 by PPM1D expression — UCEC

Explore this box plot interactively →