PPM1D

Across TCGA cell cohorts, PPM1D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,563 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPM1D-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Constitutive heterochromatin formation, and Heterochromatin formation. Each is linked with PPM1D in more than 15 cancer types. Because this analysis shows association rather than direction, both PPM1D-to-partner and partner-to-PPM1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by PPM1D-low versus PPM1D-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1D→partner) and Y-score (partner→PPM1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of beige fat cell differentiation →	+0.146	+0.953	<.001	<.001	3	16
STOMACH	Constitutive heterochromatin formation →	+0.117	+0.769	<.001	<.001	3	14
STOMACH	Heterochromatin formation →	+0.080	+0.847	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.054	+0.698	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.067	+0.910	<.001	.001	3	13
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.086	+1.071	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,563 associations by consensus.

Negative regulation of beige fat cell differentiation by PPM1D expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →