PPM1D

Across TCGA cell cohorts, PPM1D mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPM1D-associated genes across cancer lineages are REG1B, KRTAP1-4, and OR7A10. Each is linked with PPM1D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1D-to-partner and partner-to-PPM1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by PPM1D-low versus PPM1D-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1D→partner) and Y-score (partner→PPM1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	2
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1
SKIN	OR7A10 →	+0.014	+4.437	<.001	.004	3	1
SKIN	OR2K2 →	+0.051	+4.562	<.001	<.001	3	1
SKIN	TBPL2 →	+0.042	+3.684	<.001	.006	3	1
SKIN	VN1R5 →	+0.023	+4.054	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

REG1B by PPM1D expression — BREAST

Explore this box plot interactively →