PPM1AP1

Across TCGA pan-cancer cohorts, PPM1AP1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PPM1AP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPM1AP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PPM1AP1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where PPM1AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.207	<.001	11	view →
THCA	Female	II,III,IV	+0.206	<.001	9	view →
HNSC	All	III,IV	+0.142	.001	8	view →
KICH	All	All	−0.225	<.001	6	view →
CHOL	All	All	+0.181	.002	3	view →
READ	All	III,IV	−0.175	<.001	2	view →
LUSC	All	All	+0.115	.014	2	view →
LUAD	Female	III,IV	−0.131	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PPM1AP1–KIRC

Open the KIRC breakdown →