PPM1A

Across TCGA pan-cancer cohorts, PPM1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPM1A data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPM1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPM1A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where PPM1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.922	0.490	<.001	71	view →
HNSC	DFS	Tertile	III,IV	0.185	1.000	.006	31	view →
LUAD	DFS	Median	III,IV	0.289	0.763	.004	18	view →
GBM	DFS	Tertile	All	0.776	0.653	.014	10	view →
LSCC	DFS	Median	All	0.644	0.896	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPM1A–CCRCC (DFS)

Open the CCRCC breakdown →