PPM1A

Across TCGA patient cohorts, PPM1A mutation is significantly associated with the RNA expression of many other genes, with 2,309 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1A-associated genes across cancer lineages are RNU6-131P, ANKRD49P3, and PSAT1P4. Each is linked with PPM1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1A-to-partner and partner-to-PPM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-131P grouped by PPM1A-low versus PPM1A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1A→partner) and Y-score (partner→PPM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-131P →	+0.365	+4.680	<.001	.007	3	2
CESC	ANKRD49P3 →	+0.060	+5.103	<.001	.008	3	2
COAD	PSAT1P4 →	+0.313	+3.463	<.001	.006	3	2
COAD	ANAPC15P1 →	+0.367	+3.289	.006	.008	3	2
CESC	SUN5 →	+0.030	+5.306	<.001	.006	3	2
LUAD	ZNF123P →	+0.059	+5.444	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,309 associations by consensus.

RNU6-131P by PPM1A expression — SKCM

Explore this box plot interactively →