PPM1A

Across TCGA patient cohorts, PPM1A mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1A-associated genes across cancer lineages are ERK2, ACC_pS79, and ACC1. Each is linked with PPM1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1A-to-partner and partner-to-PPM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PPM1A-low versus PPM1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1A→partner) and Y-score (partner→PPM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.151	+2.321	.036	.033	3	2
UCEC	ACC_pS79 →	+0.309	+2.459	.017	.018	3	2
UCEC	ACC1 →	+0.333	+2.183	.014	.033	3	2
UCEC	Akt_pS473 →	+0.668	+1.765	.012	.014	3	2
UCEC	Akt_pT308 →	+0.636	+2.169	.007	.003	3	2
UCEC	ASNS →	+0.467	+1.807	<.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ERK2 by PPM1A expression — UCEC

Explore this box plot interactively →