PPL

Across TCGA pan-cancer cohorts, PPL mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPL is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and COAD are the cancer types where PPL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.221	<.001	11	view →
CCRCC	All	All	−0.296	<.001	11	view →
COAD	Male	All	−0.512	<.001	10	view →
LUAD	Male	III,IV	−1.011	<.001	9	view →
PDAC	Male	All	+0.943	<.001	9	view →
LSCC	Female	All	−1.226	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPL–HNSC

Open the HNSC breakdown →