PPL

Across TCGA patient cohorts, PPL mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPL-associated genes across cancer lineages are Caspase-7-cleavedD198, Rad50, and Cyclin-B1. Each is linked with PPL in more than 3 cancer types. Because this analysis shows association rather than direction, both PPL-to-partner and partner-to-PPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPL-low versus PPL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPL→partner) and Y-score (partner→PPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.536	+3.824	<.001	<.001	3	4
COAD	Rad50 →	-0.363	-2.674	<.001	.005	3	3
SKCM	Cyclin-B1 →	+0.744	+3.459	<.001	.004	3	3
SKCM	Rab25 →	-0.234	-2.983	.038	.034	3	3
UCEC	FoxM1 →	+0.153	+1.343	.027	.002	3	3
UCEC	IGFBP2 →	-0.694	-1.523	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Caspase-7-cleavedD198 by PPL expression — COAD

Explore this box plot interactively →