PPL

Across TCGA cell cohorts, PPL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPL-associated GO terms across cancer lineages are Rho protein signal transduction, Small GTPase-mediated signal transduction, and Vacuolar transport. Each is linked with PPL in more than 14 cancer types. Because this analysis shows association rather than direction, both PPL-to-partner and partner-to-PPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rho protein signal transduction grouped by PPL-low versus PPL-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPL→partner) and Y-score (partner→PPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Rho protein signal transduction →	+0.162	+3.566	<.001	<.001	3	15
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.075	+3.846	<.001	<.001	3	14
OESOPHAGUS	Vacuolar transport →	+0.065	+2.688	.006	.002	3	13
STOMACH	Lysosomal transport →	+0.077	+2.596	.001	.001	3	13
STOMACH	Regulation of nucleocytoplasmic transport →	+0.095	+3.294	<.001	<.001	3	13
STOMACH	Process utilizing autophagic mechanism →	+0.092	+3.581	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,177 associations by consensus.

Rho protein signal transduction by PPL expression — STOMACH

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