PPL

Across TCGA cell cohorts, PPL mutation is significantly associated with the RNA expression of many other genes, with 1,078 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPL-associated genes across cancer lineages are BUB3, CRISP2, and HMGXB4. Each is linked with PPL in more than 2 cancer types. Because this analysis shows association rather than direction, both PPL-to-partner and partner-to-PPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by PPL-low versus PPL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPL→partner) and Y-score (partner→PPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BUB3 →	+0.719	+3.199	.001	.007	3	3
SOFT_TISSUE	CRISP2 →	+0.090	+3.297	<.001	.001	3	2
LARGE_INTESTINE	HMGXB4 →	+0.694	+3.526	<.001	<.001	3	2
LARGE_INTESTINE	METTL4 →	+0.610	+3.067	.001	.009	3	2
LARGE_INTESTINE	UBTF →	+0.653	+3.131	.003	.008	3	2
LARGE_INTESTINE	RPF1 →	+0.695	+3.588	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,078 associations by consensus.

BUB3 by PPL expression — BLOOD_Leukemia

Explore this box plot interactively →