PPIP5K2

Across TCGA pan-cancer cohorts, PPIP5K2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPIP5K2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPIP5K2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPIP5K2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where PPIP5K2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.471	1.000	.002	16	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.478	.001	16	view →
HNSC	DFS	Tertile	III,IV	0.535	0.806	.024	3	view →
CCRCC	OS	Tertile	All	0.687	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPIP5K2–PDAC (OS)

Open the PDAC breakdown →