PPIP5K2

Across TCGA patient cohorts, PPIP5K2 mutation is significantly associated with the RNA expression of many other genes, with 2,687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIP5K2-associated genes across cancer lineages are C16orf95, ANKRD39, and HES6. Each is linked with PPIP5K2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPIP5K2-to-partner and partner-to-PPIP5K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf95 grouped by PPIP5K2-low versus PPIP5K2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIP5K2→partner) and Y-score (partner→PPIP5K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C16orf95 →	+0.233	+1.906	<.001	<.001	3	3
SKCM	ANKRD39 →	+0.693	+3.507	<.001	.002	3	3
UCEC	HES6 →	+0.854	+2.408	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.534	+2.447	<.001	<.001	3	3
READ	YWHAQP1 →	+0.200	+5.257	<.001	.002	3	2
UCEC	MRPS11 →	+0.320	+2.042	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,687 associations by consensus.

C16orf95 by PPIP5K2 expression — UCEC

Explore this box plot interactively →